. Author manuscript; available in PMC: 2015 Dec 1.

Published in final edited form as: Comput Methods Biomech Biomed Engin. 2013 Mar 12;17(16):1809–1820. doi: 10.1080/10255842.2013.767336

Table 4.

Design of experiments (DOE) analysis indicates significant relationships (p<0.05) between model parameters and outcome measures. (+/− indicate positive/negative effect on outcome measures.)

Parameter	Levels	Shear Stress (Pa)	Pressure (Pa)	Fluid Velocity (m/s)
R²		0.54	0.63	0.74
Viscosity (Pa-s)	0.001 – 0.1	+	+
Gap closing fraction (GCF)	0.1 – 0.8	+	+	+
Gap thickness (mm)	0.005 – 0.03		−	+
Loading direction	Axial - shear			−
Loading frequency (Hz)	1 – 4		+
Viscosity * GCF		+	+
Viscosity * Gap			−
GCF * Gap				+
GCF * Load Direction				−
GCF * Frequency				+
Load Direction * Gap				−