Fig. 2.

Overlay of β₂AR-G_s complex with GDP-bound heterotrimeric G protein Gαβγ_i (PDB files 3SN6 and 1GP2, respectively). Gα_s shown in blue, β₂AR in orange, and Gα_i in red. Note that there is no high resolution of Gα_sGDP available for this comparison. A. Overview showing proximity of α5, αA and αG helices to bound GDP (sticks). B. Close up, rotated and slab view, showing proximity of P loop, α5, αG and αA to bound nucleotide.