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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Mol Immunol. 2013 May 9;56(0):48–56. doi: 10.1016/j.molimm.2013.03.022

Figure 5.

Figure 5

Replacing the −45 NFAT site with a NFAT/AP-1 composite element results in high synergistic activation with NFATc2 and cJun/cFos. For the mutant reporter, a NFAT/AP-1 composite element replaced the single NFAT site at −45 while maintaining the orientation of the NFAT site relative to the TSS. Overexpression of cJun or cJun/cFos in combination with NFATc2 resulted in high synergistic activation on the mutant NFAT/AP-1 composite reporter. Bars are the average of three transfections and error bars represent one standard deviation.