Table 4.
Gynecologic and reproductive history of female Primary Biliary Cirrhosis cases and controls.
| PBC | Controls | P-value* | |
|---|---|---|---|
| Median age at first menarche# | 13.0 (9.0 – 17.0) | 13.0 (8.0 – 19.0) | 0.84 |
|
| |||
| Median age menstruation ceased# | 48.0 (21.0 – 59.0) | 48.0 (20.0 – 65.0) | 0.56 |
|
| |||
| Ever pregnant | 90% | 88% | 0.27 |
|
| |||
| Median number of pregnancies# | 3.0 (0.0 – 10.0) | 3.0 (0.0 – 15.0) | 0.7 |
|
| |||
| Median number of live births# | 2.0 (0.0 – 7.0) | 2.0 (0.0 – 9.0) | 0.11 |
|
| |||
| Median age at first pregnancy# | 21.5 (15.0 – 46.0) | 22.0 (14.0 – 37.0) | 0.29 |
|
| |||
| Pruritus during pregnancy | 14% | 6% | 0.01 |
|
| |||
| Oral contraceptives | |||
| Ever taken contraceptives | 75% | 75% | 0.82 |
|
| |||
| Median age of contraceptive start# | 21.0 (12.0 – 45.0) | 21.0 (14.0 – 45.0) | 0.07 |
|
| |||
| Number of years using contraceptives | 0.02 | ||
| Less than 1 year | 17% | 10% | |
| 1–5 years | 35% | 39% | |
| 6–10 years | 27% | 22% | |
| 11 or more years | 20% | 29% | |
|
| |||
| Hormone replacement therapy | |||
| Ever taken hormone replacement | 64% | 61% | 0.15 |
|
| |||
| Median age hormone replacement started# | 49.0 (14.0 – 69.0) | 48.0 (15.0 – 70.0) | 0.11 |
PBC: Primary Biliary Cirrhosis
*
adjusted for age at time of recruitment and education
#
variables summarized as median (min - max)