Table 6.

Summary of odds ratios from published Primary Biliary Cirrhosis case-control risk factor studies: familial, medical, and reproductive measures.

	Corpechot15	Prince14	Gershwin13	MCPGE Registry
PBC cases	222	318 Epidemiological Cases *	1,032	522
		2,258 Foundation Cases **
Controls	509	2,438	1,041	616
Family history of PBC	OR = 6.8 (FDR)	OR = 2.3*	OR = 10.7 (FDR)	OR = 5.7 (FDR)
		OR = 4.4**	OR = 12.1
Sjögren syndrome	OR = 11.9	n/a	OR = 22.7	OR = 10.2 (P < 0.001)
Family history of Sjögren syndrome	NS	n/a	OR = 5.8	n/a
Raynaud syndrome	OR = 7.2	n/a	OR = 5.7	OR = 3.8 (P < 0.001)
History of autoimmune disease	OR = 6	n/a	OR = 3.2	OR = 4.2 (P < 0.001)
Tobacco
Current	OR = 1.7	OR = 1.5*, OR = 1.4**	OR = 2	OR = 1.4 (P = 0.29)
Significant history	NS	OR = 1.6*, OR = 1.5**	OR = 1.6	OR = 1.6 (P < 0.001)
		OR = 1.6*, OR = 1.6**
Second-hand exposure	OR = 3.5	n/a	n/a	OR = 1.6 (P = 0.01)
Urinary tract infections	OR =2.7	OR = 2.1*, OR = 1.8**	OR = 1.5	OR = 1.7 (P < 0.001)
		OR = 2.4*, OR = 1.7**	OR = 1.4
Tonsillectomy	NS	OR = 2.4*, OR = 1.7**	OR = 1.3	OR = 1.5 (P = 0.001)
		NS*, OR = 1.7**
Cholecystectomy	OR = 1.8	n/a	OR = 1.8	OR = 2.6 (P < 0.001)
Any type vaccine	OR = 0.4	n/a	n/a	n/a
Tetanus vaccine	OR = 0.3	n/a	n/a	n/a
Influenza vaccine	OR = 0.3	n/a	n/a	OR = 0.9 (P = 0.42)
	n/a	n/a	n/a	OR = 1.4 (P = 0.01)
Measles
OCP	OR = 0.6	n/a	NS	OR = 1.0 (P = 0.82)
	OR = 0.7
HRT	NS	n/a	OR = 1.5	OR = 1.2 (P = 0.15)
			OR = 1.6
Pregnancy pruritus	OR = 3.9	OR = NS*, OR = 2.1**	n/a	OR = 2.0 (P = 0.01)
		OR = 2.1*, OR = 2.2**
Abortion	OR = 2	n/a	n/a	n/a

PBC: Primary Biliary Cirrhosis

OR: Odds Ratio

MCPGE Registry: Mayo Clinic PBC Genetic Epidemiology Registry

FDR: Analysis included first-degree relatives only

OCP: Oral Contraceptive Pills

HRT: Hormone replacement therapy

NS: Not statistically significant

n/a: not available for analysis

^*Epidemiologic cases¹⁴

^**Foundation cases¹⁴

Italics: Odds ratio calculated from associated study multivariate analysis