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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Mol Cancer Res. 2013 Mar 14;11(6):568–578. doi: 10.1158/1541-7786.MCR-12-0710

Figure 1. High throughput RNAi screening identifies suppressors of CRPC growth.

Figure 1

Pools of siRNAs targeting 6650 genes (Library) were used to knockdown individual gene targets in LNCaP and VCaP cells grown in androgen-depleted medium. HTRS Z-score results are plotted for the LNCaP (A) and VCaP (B) cell lines. siUNI is a non-targeting scrambled control siRNA. siKif11 is a positive control cell death-inducing siRNA targeting Kif11. (C) In the library screen, 380 siRNAs and 240 siRNAs induced castration-resistant growth in LNCaP or VCaP, respectively. Of these, 40 genes induced growth in androgen depleted conditions in both cell lines (Significance threshold: Z≥1.96).