Table 1.

Treatment Protocol Overview

	Protocol A1	Protocol A2	Protocol B1	Protocol B2
Standard initial fluid bolus *	10 cc/kg bolus of 0.9% saline	10 cc/kg bolus of 0.9% saline	10 cc/kg bolus of 0.9% saline	10 cc/kg bolus of 0.9% saline
Additional intravenous fluid bolus	Additional 10 cc/ kg of 0.9% saline	Additional 10 cc/ kg of 0.9% saline	No additional bolus	No additional bolus
Assumed fluid deficit	10% of body weight	10% of body weight	5% of body weight	5% of body weight
Replacement of deficit	replace half of fluid deficit + maintenance fluids over initial 12 hours, remaining deficit + maintenance fluids over subsequent 24 hours	replace half of fluid deficit + maintenance fluids over initial 12 hours, remaining deficit + maintenance fluids over subsequent 24 hours	replace deficit + maintenance fluids evenly over 48 hours	replace deficit + maintenance fluids evenly over 48 hours
Fluid used for deficit replacement	0.45% saline	0.9% saline	0.45% saline	0.9% saline

^*NOTE: This is standard treatment at all participating centers and is not part of the study protocol. Consent will occur during this initial fluid bolus after which the study treatment will be randomized.