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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Mol Cancer Res. 2013 Feb 28;11(6):638–650. doi: 10.1158/1541-7786.MCR-12-0634-T

Figure 3. Representative formalin-fixed paraffin-embedded sections of subcutaneous xenografts derived from HBEC3p53,KRAS and HBEC3p53,KRAS,MYC.

Figure 3

HBEC3p53,KRAS and HBEC3p53,KRAS,MYC formed subcutaneous tumor reflective of naturally arising lung carcinomas with adenosquamous differentiation (top panel), adenocarcinoma (middle panel on left), and squamous differentiation (lower panel on left), as well as undifferentiated large cell carcinomas, some of which also exhibited a giant cell component (middle and lower panels on right). Squamous and adenocarcinoma differentiation was confirmed with p63 and mucicarmine and/or alcian-blue PAS staining, respectively. The example of adenosquamous cell carcinoma (top panel) clearly shows dual differentiation of peripheral squamous/basal-like cells (p63+/mucin−) and central glandular cells (p63−/mucin+). H&E, hematoxylin and eosin; Muc, mucicarmine; AB-PAS, alcian-blue PAS. Original magnification of images at 10X except adenosquamous H&E and P63 (20X); Large cell carcinoma with giant cell component H&E (20X); and Large cell carcinoma H&E (40X).