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. Author manuscript; available in PMC: 2014 Jun 15.
Published in final edited form as: Cancer Res. 2013 Apr 10;73(12):3671–3682. doi: 10.1158/0008-5472.CAN-12-4453

Figure 7. Sensitization of BT-474R cells to Trastuzumab.

Figure 7

Effect of Pak and β-catenin inhibitors on survival of BT-474R cells. (A) Cells were treated with the indicated amounts of PF-3758309 and/or iCRT14 for 4 days and the viability was determined by trypan blue exclusion. (B) Combination of PF-3758309 and/or iCRT14 treatment sensitizes BT-474R cells to trastuzumab. Cells were treated with the indicated amounts of PF-3758309 and/or iCRT14 in the presence or absence of trastuzumab for 4 days, collected and apoptosis was measured calculating the percent of positive Annexin V-PE cells by flow cytometry. The data are representative of three independent experiments. Bars, SD. *p<0.05.