. Author manuscript; available in PMC: 2014 Jun 15.

Published in final edited form as: Cancer Res. 2013 Apr 10;73(12):3671–3682. doi: 10.1158/0008-5472.CAN-12-4453

Table 1. Synergistic effects of Pak plusβ-catenin inhibitors.

Summary results of drug interactions calculated as Chou-Talalay CI based on CellTiter-Blue viability determinations. CI values <1 indicate synergy, and <0.5 (in bold) strong synergy, between the two agents in producing cytotoxic effect

Cell line	Inhibitors		Molar Ratio	CI (average ± std. dev)
Cell line	Inhibitors		Molar Ratio	ED50	ED75	ED95
BT-474	PF-3758309	iCRT14	1:1	0.368 ± 0.025	0.416 ± 0.026	0.512 ± 0.033
	PF-3758309	iCRT3	1:1	0.396 ± 0.037	0.429 ± 0.032	0.543 ± 0.042
	PF-3758309	JW55	1:1	0.982 ± 0.015	1.002 ± 0.013	1.021 ± 0.098
SK-BR3	PF-3758309	iCRT14	1:1	0.314 ± 0.002	0.330 ± 0.114	0.417 ± 0.144
	PF-3758309	iCRT3	1:1	0.402± 0.096	0.472± 0.103	0.582 ± 0.025
	PF-3758309	JW55	1:1	0.928 ± 0.016	0.982 ± 0.031	1.052 ± 0.028