. 2012 Dec 19;4(1):1–11. doi: 10.1007/s13300-012-0017-4

Table 3.

Impact of an ABC on hypoglycemia

References	Study design	Objectives	Results
Barnard et al. [41]	Survey of 588 MDI-treated type 1 diabetic patients using an ABC	Reduced fear of hypoglycemia	Mild or significant reduction in fear of hypoglycemia in 52% of respondents
		Prognosis of patients to achieve improved glycemic control	Improvement or significant improvement in the confidence in the insulin dose calculation in 78.8% of respondents
		Prognosis of patients to achieve improved glycemic control	Bolus calculation made easy or very easy by the ABC in 89.3% of respondents
Bergenstal et al. [42]	12-week intervention period (testing the Diabetes Insulin Guidance system following a 4-week baseline run-in period	Primary: fraction of software dosage adjustment approved by the study team	Improvement in average BG levels (P < 0.03)
	20 MDI-treated CC type 1 diabetes patients, 20 MDI-treated non-CC type 2 diabetes patients, and six twice-daily biphasic-treated type 2 diabetes patients	Secondary: improved glycemic control	Improvement in mean HbA_1c (P < 0.03)
		Secondary: improved glycemic control	Reduction by 25.2% of hypoglycemic events (P = 0.02)

ABC automated bolus calculator, CC carbohydrate counters, BG blood glucose, HbA _1c glycated hemoglobin, MDI multiple daily injection