Figure 1.

Structural variability of proteins encoded by TNR-containing genes. Illustrative domain graphics of the multi-domain structure of proteins associated with polyQ-expansion diseases. All proteins shown are referenced by their name as annotated in UniProt. The protein domains for which information is annotated in the Pfam database are shown as colored boxes with Pfam family accession code referenced above the domain box. Complete names of domains can be assessed by searching the specific Pfam accession code at http://pfam.sanger.ac.uk/. Numbers below the domain schemes represent amino acid residue numbers. Regions containing the amino acid repeats and with a prediction for formation of coiled-coils (as annotated in UniProt) are shown as well as regions with known 3D structure (boxed in red, with PDB accession codes shown). Notice the predominant location of the repeat regions within the N-terminal regions of the proteins.