Figure 5.

Overview of ataxin-3 protein interaction network. Data on the ataxin-3 interactors was obtained by analysis of Interactome3D (Mosca et al., 2012), MINT (Ceol et al., 2010), and Dr. PIAS (Sugaya and Furuya, 2011) protein interaction databases, and completed with data compiled from current literature on ataxin-3 protein associations obtained with a diverse set of experimental approaches (see complete information on Table 2). Red arrows indicate interactions for which structural data has been obtained, while orange arrows indicate that biophysical data on interaction affinity in vitro is known (Table 2). Broken arrows represent interactions that result from high-throughput interactome analysis that still require detailed biochemical and functional analysis. Proteins are grouped according to their biological role.