Figure 1.

Risk of diabetes complications and adverse events associated with diabetes drug therapies expressed as absolute risk per 1,000 patient-years. Black bars show representative values for risk in diabetic patients, and gray bars indicate excess risk of events in patients treated with specific glucose-lowering medications relative to diabetic patients receiving comparator therapies. Incidence rates are subject to considerable variation with age, duration of diabetes, and concomitant morbidity. Adapted with permission from Bergenstal et al. (13). Data were derived from references 13–28. ACCORD, Action to Control Cardiovascular Risk in Diabetes; CHF, congestive heart failure; PVD, peripheral vascular disease; UKPDS, U.K. Prospective Diabetes Study.