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. 2013 May 23;105(12):849–859. doi: 10.1093/jnci/djt101

Figure 5.

Figure 5.

Kaplan–Meier survival analysis in colorectal cancer (CRC) patients based upon miR-21 expression in primary tumors and matched serum samples. A) The overall survival rate in CRC patients with high miR-21 expression in tumor tissue (n = 25) was statistically significantly lower than that for those with low miR-21 expression (n = 141) (>3.7 vs ≤3.7; P = .006; log-rank test). B) The overall survival rate in CRC patients with high serum miR-21 expression (n = 126) was statistically significantly lower than that for those with low serum miR-21 expression (n = 62) (>0.003 vs ≤.003; P = .005; log-rank test). Cutoff values for miR-21 expression in serum and primary tumor tissues were determined from the receiver operating characteristic curves by using Youden’s index. The number of patients at risk are shown below each curve at various timepoints.