Table 3.
Univariate and multivariable analyses of factors predictive of poor overall survival in colorectal cancer patients*
| Variables | Univariate† | Multivariable‡ | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age#, >67 y vs ≤67 y | 0.72 (0.43 to 1.37) | .37 | 1.23 (0.57 to 2.67) | .59 |
| Sex, female vs male | 1.02 (0.56 to 1.86) | .92 | 2.07 (0.86 to 4.96) | .10 |
| Pathological T, T3/4 vs T1/2 | 8.97 (2.19 to 36.70) | .002 | 2.38 (0.30 to 29.77) | .31 |
| Pathology, poor diff. vs diff. | 2.26 (1.05 to 4.84) | .04 | 2.39 (0.57 to 9.92) | .23 |
| Lymph node metastasis, yes vs no | 17.1 (6.18 to 47.80) | <.001 | 6.83 (1.69 to 28.36) | .008 |
| Distant metastasis, yes vs no | 35.6 (14.40 to 86.60) | <.001 | 21.7 (5.92 to 79.99) | <.001 |
| CEA§, >5ng/mL vs ≤5ng/mL | 4.84 (2.15 to 10.89) | .001 | 1.03 (0.33 to 3.22) | .94 |
| miR-21 in tissue¶, >3.7 vs ≤3.7 | 2.66 (1.29 to 5.45) | .01 | 0.59 (0.21 to 1.63) | .31 |
| miR-21 in serum¶, >0.0031 vs ≤0.0031 | 3.25 (1.36 to 7.73) | .003 | 4.12 (1.10 to 15.40) | .03 |
* CEA = carcinoembryonic antigen; CI = confidence interval; diff. = differentiation; HR = hazard ratio.
# The median age was 67 years.
§ Cutoff value for CEA is 5ng/mL (as per American Association of Clinical Oncology recommendations).
¶ Cutoff values of miR-21 in tissue and serum are derived from receiver operating characteristic curve with Youden’s index.
† Univariate analysis was performed using clinical data available from 200 patients, serum miR-21 data from 186 patients, and tissue miR-21 data from 166 colorectal cancer patients, respectively..
‡ Multivariable analysis was performed using data from 153 colorectal cancer patients from whom matched matching data were available for all clinico-pathological factors as well as serum and tissue miR-21 expression results.