FIG. 1.

Basic design of retroviral vectors. (A) Retroviral vectors with anti-HIV activity code for a protein that consists of the following modules: a signal peptide to direct translocation into the endoplasmic reticulum (SP), the antiviral C peptide (C46), a hinge (H), and an MSD. Some vectors coexpress the neomycin resistance gene via a poliovirus internal ribosome entry site as a marker or express an RRE decoy or a wPRE element in the 3′ UTR. (B) Amino acid sequence of the membrane-anchored antiviral peptide encoded by M87o. LTR, long terminal repeat.