PEGylation protects VSV-G-HIV from inactivation in the presence of human serum (A) and sera from C57BL/6 mice (B). Percent survival is the ratio of the titer of the virus after incubation in the presence of serum to the titer of virus incubated in saline. The data represent results obtained from three different lots of serum (mouse and human), and the error bars represent the standard deviations of the data. FBS, control; HIS, heat-inactivated human serum; NHS, normal human serum; HIMS, heat-inactivated mouse serum; NMS, normal mouse serum. *, P ≤ 0.05 (Student's t test).