TABLE 1.
Pharmacokinetic parameters from concentration versus time curves of animals after a single intravenous dose of unmodified and PEGylated VSV-G pseudotyped lentiviral vectors
| Parametera | Treatment group
|
|||
|---|---|---|---|---|
| VSV-G
|
VSV-G-PEG
|
|||
| Viral titer | p24 | Viral titer | p24 | |
| Cmax | 1.4 × 106 | 734.0 | 2.21 × 107 | 780.0 |
| tmax (h) | 0.008 | 0.008 | 0.25 | 0.003 |
| t1/2 (h) | 0.55 | 4.65 | 2.84 | 3.73 |
| AUC0-∞ | 7.83 × 104 | 4,312 | 8.45 × 107 | 3,694 |
| CL (ml/h) | 277.2 | NDb | 0.257 | ND |
| Vss (ml) | 72.4 | ND | 1.04 | ND |
a
Area units for viral titer and p24 versus time curves are TU·h/ml and pg·h/ml, respectively. CL, systemic clearance rate; Vss, apparent volume of distribution at steady state.
b
ND, not determined.