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. 2013 Jun 5;2013:704912. doi: 10.1155/2013/704912

Table 1.

Characteristics of HCV direct-acting antiviral classes.

Characteristic Protease inhibitors Protease inhibitors Polymerase inhibitors Polymerase inhibitors NS5A inhibitors
First generation Second generation Nucleoside analogs Non-nucleoside analogs

Potency High Variable among HCV genotypes High Variable Moderate Consistent across genotypes Variable Variable among HCV genotypes High Multiple HCV genotypes

Barrier to resistance Low Low High Very low Low

PK Variable qd-tid qd qd Variable qd-tid qd

Adverse event Rash (SJS, TEN), anemia, hyperbilirubinemia appetite loss, renal toxicity, elevation of uric acid Anemia hyperbilirubinemia Mitochondrial nuclear interaction (RBV) Variable Variable

Drug Telaprevir Boceprevir Simeprevir Asunaprevir Faldaprevir Sofosbuvir Mericitabine BMS-791325 Daclatasvir

Clinical trial TVR: ADVANCE [7], ILLUMINATE [8], REALIZE [9]
BCV: SPRINT-2 [10], RESPOND-2 [12]
SMV: PILLAR [14], ASPIRE [15]
ASV: AI447-011 [16]
FDV: SILEN-C2 [17], SOUND-C2 [18, 19]
SOF: ATOMIC [20], ELECTRON [21]
MRB: JUMP-C [22], INFORM-1 [23], INFORM-SVR [24]
DCT: AI447-011 [25]

Comments Better barrier, pan-genotypic Single target active site Allosteric, many targets Multiple antiviral mechanisms of action

PK: pharmacokinetics; qd: once a day; tid: three times a day; RBV: ribavirin.

Modified from [1].

SJS: Stevens-Johnson syndrome; TEN: toxic epidermal necrolysis; TVR: telaprevir; BCV: boceprevir; SMV: simeprevir; ASV: asunaprevir; FDV: faldaprevir; SOF: sofosbuvir; MRB: mericitabine; DCV: daclatasvir.