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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: Cell. 2013 Apr 18;153(3):692–706. doi: 10.1016/j.cell.2013.04.002

Figure 5. TET/TDG activities are preferentially recruited to active enhancers and distal pluripotency TF binding sites in mouse ESCs.

Figure 5

(A) Heat maps of 5mC/5hmC/5fC/5caC levels (normalized read density) in control and Tdg-deficient cells at centers of tissue-specific enhancers.

(B) Average 5mC/5hmC/5fC/5caC signals in control and Tdg-deficient mouse ESCs at the center of binding sites for pluripotency TFs (Oct4/Nanog/Sox2) and neuronal TFs.

(C) 5mC/5hmC/5fC/5caC levels in control and Tdg-deficient mouse ESCs at a representative locus (upstream of the Zfp281 gene) of binding sites of pluripotency TFs (Oct4/Nanog/Sox2). Other genomic features (e.g. DNase I hypersensitivity sites, H3K4me1 enriched regions, LMRs and enhancer-related epigenetic regulator LSD1) are also shown.

See also Figure S5.