Fig. 1.

Schematic illustrating different computational models of invasive cell cohorts. a) Cellular automata model in which each cell occupies a single grid site; b) Cell-centered grid-free model in which each cell is defined as a points (nucleus); c) Cellular Potts model in which each cell is composed of several grid sites defining cell shape and area; d) IBCell model in which each cell consists of a deformable elastic membrane filled with gel-like cytoplasm; e) Continuous models in which each region represents mass (population, density) of cells of the same type.