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. 2013 May 27;169(4):900–908. doi: 10.1111/bph.12161

Table 2.

Effects of stress on SBP, MBP, DBP, HR and BRS in rats pretreated with V1a-receptor antagonist or vehicle (10% DMSO)

I.C.V. SBP (mmHg) MBP (mmHg) DBP (mmHg) HR (bpm) BRS (ms·mmHg−1)
BASELINE 10% DMSO (5 μL) 123 ± 4 96 ± 4 83 ± 4 390 ± 16 1.4 ± 0.2
STRESS 10% DMSO (5 μL) +20 ± 4** +22 ± 4** +23 ± 5** +55 ± 12* 0.66 ± 0.2 *
BASELINE V1a (100 ng·5 μL−1) 120 ± 4 96 ± 3 84 ± 3 370 ± 10 1.4 ± 0.3
STRESS V1a (100 ng·5 μL−1) +15 ± 3** +16 ± 3** +16 ± 3** +59 ± 19* 0.75 ± 0.1 *
BASELINE V1a (500 ng·5 μL−1) 120 ± 5 95 ± 4 82 ± 3 395 ± 13 1.8 ± 0.3
STRESS V1a (500 ng·5 μL−1) +12 ± 1* +10 ± 5* +9 ± 2* 50 ± 22 * 1.1 ± 0.4*

Values are mean ± SEM of six experiments. Stress increases SBP, MBP, DBP, HR and decreases BRS. Note that V1a antagonist pretreatment does not modify the stress response. *P < 0.05, **P < 0.01 versus corresponding baseline.