Table 2.
I.C.V. | SBP (mmHg) | MBP (mmHg) | DBP (mmHg) | HR (bpm) | BRS (ms·mmHg−1) |
---|---|---|---|---|---|
BASELINE 10% DMSO (5 μL) | 123 ± 4 | 96 ± 4 | 83 ± 4 | 390 ± 16 | 1.4 ± 0.2 |
STRESS 10% DMSO (5 μL) | +20 ± 4** | +22 ± 4** | +23 ± 5** | +55 ± 12* | 0.66 ± 0.2 * |
BASELINE V1a (100 ng·5 μL−1) | 120 ± 4 | 96 ± 3 | 84 ± 3 | 370 ± 10 | 1.4 ± 0.3 |
STRESS V1a (100 ng·5 μL−1) | +15 ± 3** | +16 ± 3** | +16 ± 3** | +59 ± 19* | 0.75 ± 0.1 * |
BASELINE V1a (500 ng·5 μL−1) | 120 ± 5 | 95 ± 4 | 82 ± 3 | 395 ± 13 | 1.8 ± 0.3 |
STRESS V1a (500 ng·5 μL−1) | +12 ± 1* | +10 ± 5* | +9 ± 2* | 50 ± 22 * | 1.1 ± 0.4* |
Values are mean ± SEM of six experiments. Stress increases SBP, MBP, DBP, HR and decreases BRS. Note that V1a antagonist pretreatment does not modify the stress response. *P < 0.05, **P < 0.01 versus corresponding baseline.