Figure 5.
Inhibitory effect of NAGly on NCXpm currents is reversible, concentration-dependent and non-mode selective. (A, B) Representative time course (A) and NCXpm currents elicited by voltage ramps (B) before (control), during 0.3 μM NAGly administration (NAGly) and following NAGly washout. Similar results were obtained in four cells. (C, D). Representative time course (C) and NCXpm currents elicited by voltage ramps showing concentration-dependent inhibition of current responses by NAGly. Bepridil (50 μM) was administered at the end of the protocol. (D, E) Concentration-dependent inhibition of forward (D) and inward (E) NCXpm currents by NAGly. In parentheses are the numbers of individual cells treated with different concentrations of NAGly.