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. 2013 Mar 20;99(1):24–34. doi: 10.1093/cvr/cvt064

Figure 3.

Figure 3.

CYP1B1 is critical for Dfen-induced proliferation of PAH-PASMCs. (A and B) Dfen-mediated proliferation of PAH-PASMCs in the presence of both FBS (n = 3) or PDGF (n = 3). (C) Dfen up-regulates expression of CYP1B1 in PAH-PASMCs as assessed by western blot (n = 3). (D) Dfen-mediated proliferation is inhibited in the presence of the selective CYP1B1 inhibitor TMS (1 µM) (n = 3). (E) Norfenfluramine had no effect on proliferation of PAH-PASMCs (n = 3). Data are expressed as mean ± SEM. Data were analysed by one-way ANOVA followed by Dunnett's post-test. *P < 0.05, **P < 0.01 vs. 2.5% serum or 10 ng/mL PDGF, ƒP < 0.05, ƒƒP < 0.01 vs. control †P < 0.05 vs. Dfen.