Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
17β-Oestradiol and Dfen have synergistic effects on PAH-PASMC proliferation. 17β-Oestradiol mediates an increase in (A) CYP1B1 (n = 3) and (B) Tph1 (n = 3) expression in PAH-PASMCs. (C) Dfen and 17β-oestradiol have synergistic effects on proliferation of PAH-PASMCs (n = 3). Data are expressed as mean ± SEM. Data were analysed by one-way ANOVA followed by Dunnett's post-test. *P < 0.05 vs. 0.3 µM Dfen P < 0.01 vs. 0.1 nM 17β-estradiol, **P < 0.01 vs. control.
