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. 2013 Apr 3;99(1):175–184. doi: 10.1093/cvr/cvt083

Figure 2.

Figure 2

ROS and pro/antioxidant gene expression in non-myxomatous and myxomatous human mitral valves. (A and B) Micrographs and quantitation of dihydroethidium staining in non-myxomatous and myxomatous human mitral valves. Note that ROS are significantly increased in valve tissue from patients with MMVD (n= 5 non-myxomatous valves, n= 5 myxomatous valves). (C–F) Expression of pro- and antioxidant genes in non-myxomatous and myxomatous human mitral valve tissue. Expression of Nox2 (C), Nox4 (D), and SOD1 (E) is significantly increased in myxomatous tissue. (F–H) Expression of other SOD isoforms (SOD2 and SOD3) and catalase was relatively unchanged (n= 24 non-myxomatous valves, n= 24 myxomatous valves for panels (C)–(F). *P < 0.05 in all figures.