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. 2013 Apr 3;99(1):175–184. doi: 10.1093/cvr/cvt083

Figure 4.

Figure 4

ROS and pro-oxidative gene expression in wild-type and SOD1-deficient mice mitral valves. (A and B) Micrographs and quantitation of dihydroethidium staining in wild-type and SOD1-deficient mitral valves. Note that ROS are significantly increased in valve tissue from mice lacking two copies of SOD1 (n= 4 wild-type valves, n= 4 knockout valves). (C and D) Pro-oxidative gene expression in mitral valves from wild-type and SOD1-deficient mice. Note that both Nox 2 and 4 are significantly increased in SOD1-deficient mice (n= 9 wild-type valves, n= 13 knockout valves). *P < 0.05 in all figures.