Figure 3.

Relationships between the AD neurodegenerative biomarkers and PIB uptake. Distribution of the neurodegenerative biomarkers in PIB negative (BAC NC PIB− [white]) and PIB positive (BAC NC PIB+ [solid black]) individuals. A, The multimodality biomarker values were comparable for PIB+ and PIB− individuals. The gray line denotes the discriminant cutoff score (values ≤0 indicate AD classification). B–D, There were no significant differences in the single-modality biomarkers, i.e., cortical Thickness (B), FDG PET (C) and intracranial volume-adjusted hippocampal volume (HVicv) (D), between PIB+ and PIB− subjects. Error bar plots display group-means and SD for each biomarker; the gray circles indicate individual data points.