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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Gastroenterology. 2012 May 15;143(2):408–17.e2. doi: 10.1053/j.gastro.2012.05.007

Figure 6.

Figure 6

(A) VH, CD, and CPI are all significantly shorter in SERTKO mice treated with scopolamine than with vehicle. VH, CD, and CPI were quantified and expressed as the percentage of control (WT + vehicle). (B) VH, CD, and the CPI are all significantly shorter in SERTKO mice treated with ketanserin than with vehicle. (C) A hypothetical explanation of the mucosal changes seen in SERTKO mice. The deletion of SERT amplifies the effects of 5-HT that neurons secrete. Serotonergic stimulation of 5-HT2A–receptor– expressing cholinergic neurons in submucosal ganglia causes release of ACh in the mucosa, which stimulates epithelial growth. Blocking muscarinic receptors with scopolamine or 5-HT2A receptors with ketanserin thus prevent SERTKO-associated mucosal growth.