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. 2004 Jan;78(2):968–979. doi: 10.1128/JVI.78.2.968-979.2004

FIG. 3.

FIG. 3.

FIG. 3.

Maximum-likelihood phylogenetic analysis of HIV-1 protease gene sequences from plasma (red circles) of study subjects treated with HAART either later during childhood (A) or from early infancy (B). Sequence information obtained from latently infected CD4+ T cells from the early-treated group (black circles) are included in panel B to confirm the patient-specific nature of the protease sequences amplified at low levels and to emphasize the homogeneity of HIV-1 protease sequences in these individuals. Previously published plasma virus sequences are indicated in open circles (A) and are included to provide a complete picture of the evolutionary profile of HIV-1 in plasma at low levels during prolonged suppressive HAART. Reference sequences from clades A and C are labeled as follows: A*, A.SE.SE8131; A1, A.UG.U455; A2, A2.CD.CDKFE4; C*, C.IN.IN21068; C**, C.ET.ETH2220. Strain B.F.R.HXB2R was used as a reference sequence for clade B.