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. 2004 Jan;78(2):980–994. doi: 10.1128/JVI.78.2.980-994.2004

FIG. 12.

FIG. 12.

Three-step working model of coronavirus transcription. (A) The 5′-3′ complex formation step. Proteins binding the 5′- and 3′-end TGEV sequences are represented by the green ovals. The leader sequence is red, and CS sequences are yellow. An, poly(A) tail. (B) Base-pairing scanning step. Negative-strand RNA is in a lighter color than positive-strand RNA. The transcription complex is represented by the hexagon. Vertical dotted bars represent the base-pairing scanning by the TRS-L sequence in the transcription process. Vertical solid bars indicate complementarity between gRNA and the nascent negative strand. Un, poly(U) tail. (C) Template switch step. The thick arrow indicates the switch in the template made by the transcription complex to complete the synthesis of negative sgRNA.