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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Int J Low Extrem Wounds. 2013 Feb 26;12(1):4–11. doi: 10.1177/1534734612474303

Figure 2.

Figure 2

Images a–f: Representative images of H&E staining in non-DM and DM rabbit ear skin (a and b respectively), non-DM and DM rat skin (c and d) and non-DM and DM mouse skin (e and f). Black arrows indicate round inflammatory cells while green arrows indicate blood vessels. The number of infiltrating inflammatory cells were increased in all diabetic animal models when compared to non-diabetic animals (p<0.05) as well as the number of blood vessels (p<0.05). Images g, f: Representative images of H&E and CD31 staining in the same mouse skin biopsy. H&E staining (g) identified fully formed (mature) skin blood vessels. CD31 staining (h) confirmed that the identified structures in the H&E stained biopsy were blood vessels (green arrows) while it also identified additional endothelial cells that represent newly regenerating blood vessels (red arrows).