TABLE 1.
Characteristic | Active Group (n=32)
|
Placebo Group (n=11)
|
Difference | ||||
---|---|---|---|---|---|---|---|
Responder (n=14)
|
Nonresponder (n=18)
|
||||||
Mean | SE | Mean | SE | Mean | SE | ||
Age (years) | 60.1 | 2.2 | 65.9 | 2 | 61.5 | 2.5 | NS |
Education (years) | 14.9 | 0.5 | 13.1 | 0.5 | 14.6 | 0.7 | <0.05* |
HAM-D pre | 17.7 | 1.1 | 15.6 | 1.3 | 16.8 | 1.9 | NS |
HAM-D post | 8.1 | 0.7 | 13.7 | 1.2 | 13.0 | 1.6 | <0.05 |
MMSE | 28.1 | 0.5 | 27.8 | 0.4 | 27.5 | 0.5 | NS |
MRI hyperintensities (% of total brain volume) | 0.55 | 0.27 | 0.83 | 0.24 | 0.63 | 0.31 | NS |
| |||||||
n | % | n | % | n | % | ||
| |||||||
Male sex | 5 | 36 | 8 | 44.4 | 5 | 45.5 | NS |
Caucasian race | 14 | 100 | 17 | 94.4 | 11 | 100 | NS |
Married (or not living alone) | 9 | 64.3 | 10 | 55.6 | 6 | 54.6 | NS |
Hollingshead class IV or V | 2 | 14.3 | 4 | 22.4 | 0 | 0 | NS |
NS=not significant; SE = standard error; MMSE = Mini-Mental State Examination; HAM-D = Hamilton Depression Rating Scale
Data missing in two participants