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(A) Fold changes in 2-hydroxyglutarate in patients with AML with IDH mutations. (B–D) Fold changes in 2-hydroxyglutarate, 5-hydroxymethylcytosine and 5-methylcytosine in patient B (IDHMUT TET2WT) after achieving a post-cycle 1 complete remission (B) and at relapse (C), and in patient C (IDHMUT TETMUT) after achieving a post-cycle 1 complete remission (D).
