Figure 2. Pooled Risk Ratios, with 95% CI, by trial for end-points of micro and macroalbuminuria.

Footnote: Data on the incidence of micro- and macroalbuminuria from UKPDS 33 was reported in 3 year intervals. Due to the marked drop-off of patients with outcomes reported at 9 years and beyond, the data from the 6 year time-point was chosen for the endpoints of micro- and macroalbuminuria. The incidence of microalbuminuria at 9, 12, and 15 years were 19.2%, 23.0%, and 27.1% in the intensive group and 25.4%, 34.2%, and 39% in the conventional group. The incidence of macroalbuminuria at 9, 12, and 15 years was 4.4%, 6.5%, and 7.9% in the intensive group and 6.5%, 10.3%, and 12.6% in the conventional group. Intensive therapy was stopped earlier than planned in ACCORD. Data on renal outcomes were reported at transition to standard therapy (median follow-up 3.5 years) and at study end (median follow-up 5 years). The incidence of outcomes was taken from study end for the main analyses. Utilization of data from transition did not change the results for macroalbuminuria (pooled RR 0.83, 95% CI 0.72–0.95, I² = 68%) or macroalbuminuria (pooled RR 0.74, 95% CI 0.65–0.84, I² = 17%).