FIG. 6.

CCL3 gene expression within the CNS following Alb274 and Alb275 infection. (A) Densitometric analysis of CCL3 mRNA transcripts obtained from the scanned autoradiograph of an RNase protection assay. Transcripts for CCL3 were detected following both infections at all time points analyzed. CCL3 transcripts were significantly increased at day 2 postinfection following Alb274 infection compared to Alb275-infected mice (P ≤ 0.05). (B) NK cell infiltration and viral titers in CCL3^−/− mice. Alb274 infection of CCL3^−/− mice resulted in equivalent NK cell infiltration compared to Alb274-infected wild-type C57BL/6 mice at 2 days postinfection, and this correlated with no observable difference in the level of viral replication between wild-type and CCL3^−/− mice. All experiments were performed in duplicate with a minimum of three mice per experiment; n = 6.