Tat protein decreased the specific [3H]WIN35,428 binding in plasma membrane enriched fraction. Rat striatal synaptosomes were incubated with or without Tat (1 µM), and then total synaptosomal fractions (P2), plasma membrane enriched fractions (P3) and vesicle-enriched fractions (P4) were prepared and used for the specific [3H]WIN35,428 binding. * P <0.05, paired Student’s t-test.