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. Author manuscript; available in PMC: 2013 Jun 20.
Published in final edited form as: J Neuroimmune Pharmacol. 2012 May 5;7(3):629–639. doi: 10.1007/s11481-012-9369-9

Figure 4.

Figure 4

Inhibitory effects of Tat on synaptosomal [3H]DA uptake and vesicular [3H]DA uptake in rat striatum. Rat striatal synaptosomes were preincubated with or without Tat (1 µM) for 15 min. Drug was then washed off, and specific synaptosomal and vesicular uptake of 0.1 µM [3H]DA uptake were measured. Tat inhibited the specific [3H]DA uptake into vesicles (A; via VMAT2) and synaptosomes (B; via DAT) by 35% and 26%, respectively, compared to the respective control values (*P <0.05, paired Student’s t-test).