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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Bioorg Med Chem. 2013 Feb 21;21(9):2600–2617. doi: 10.1016/j.bmc.2013.02.023

Scheme 3.

Scheme 3

Synthesis of 2-pyridinylpyrimidine derivatives 16a, 16b and 18a–18p. Reagents & Conditions: (i) Cl(CH2)nCH2COCl, Et3N, THF, ∼80% yield; (ii) NaI, Na2CO3, DMF then TBAF, 67-74% yields; (iii) NaI, Na2CO3, DMF, then CF3CO2H, 62-79% yields.