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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Bioorg Med Chem. 2013 Feb 21;21(9):2600–2617. doi: 10.1016/j.bmc.2013.02.023

Scheme 5.

Scheme 5

Synthesis of sulfonamide derivatives 24a and 24b. Reagents & Conditions: (i) CH2=CHSO2Cl, Et3N, CH2Cl2, 91% yield; (ii) 15 or 17, EtOH 50 °C, 80-90% yields; (iii) TFA or TBAF, 80-84% yields.