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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Diabetes Obes Metab. 2012 Oct;14(0 3):91–100. doi: 10.1111/j.1463-1326.2012.01651.x

Figure 4.

Figure 4

[11C] FLB 457 study in one baboon at the level of the pancreas at baseline and following D2R blockade with haloperidol. Images are summed axial frames from 6 to 30 min post-injection of a bolus of [11C] FLB 457. Data are not normalized to injected activity. Time activity curves (blue squares–ROI on kidney, light blue dots – ROI on pancreas) were used to calculate a distribution volume ratio (DVR) using a reference region method. The dose of haloperidol (a D2R antagonist) administered (1 mg/kg) was expected to displace at least 30% of the specifically bound PET ligand. A kidney reference region was used to calculate the DVR. Haloperidol administration caused the apparent DVR to drop to 1.1 from 1.4.