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. 2013 Apr 10;15(1):30. doi: 10.1186/1532-429X-15-30

Table 1.

Model input parameters

Parameter Value Range Ref.
SnC
 Sensitivity of CMR
 0.82
 0.77-0.86
 [17]
SpC
 Specificity of CMR
 0.86
 0.82-0.89
 [17]
SnS
 Sensitivity of SPECT
 0.67
 0.60-0.72
 [17]
SpS
 Specificity of SPECT
 0.83
 0.79-0.86
 [17]
SnA
 Sensitivity of angiography
 1.00
 N/A
 [19-21]
SpA
 Specificity of angiography
 1.00
 N/A
 [19-21]
RC
 Complication rate with CMR
 0.0005
 0.0001-0.001
 [23]
RS
 Complication rate with SPECT
 0.0005
 0.0001-0.001
 [20]
RA
 Complication rate with angiography
 0.005
 0.001-0.01
 [28]
RF
 Complication rate for patients with CAD and false-negative test results*
 0.25
 0.15-0.30
 [20,21]
MC
 Mortality rate due to CMR
 0.00005
 0.00001-0.0001
 [20,24]
MS
 Mortality rate due to SPECT
 0.00005
 0.00001-0.0001
 [20,24]
MA
 Mortality rate due to angiography
 0.00075
 0.0001-0.0015
 [28]
MF
 Mortality rate for patients with CAD and false-negative test results*
 0.20
 0.15-0.25
 [19,20]
NDxC
 Rate of non-diagnostic CMR
 0.05
 0.01-0.1
 [17,25]
NDxS
 Rate of non-diagnostic SPECT
 0.05
 0.01-0.1
 [17,25]
NDxA
 Rate of non-diagnostic angiography
 0.00
 N/A
 [19-21]
CC
 Cost of CMR [in €]
 703
 527-879
 [31,34]
CS
 Cost of SPECT [in €]
 504
 378-630
 [30,33]
CA
 Cost of angiography [in €]
 2,926
 2,195-3,658
 [29,35]
C
 Cost of a complication# [in €]
 14,478
 10,859-18,098
 [21,36]
NC
 No. of patients having CMR
 1.0
 N/A
 [21]
NS
 No. of patients having SPECT
 1.0
 N/A
 [21]
NA
 No. of patients having angiography
 varies
 Equation 1a
 [19-21]
NFC
 No. of false-negative CMR
 varies
 Equation 1a
 [19-21]
NFS
 No. of false-negative SPECT
 varies
 Equation 1a
 [19-21]
P
 Prevalence of CAD
 varies
 0.1-1.0
 [19-21]
ΔQALY’
 QALY extended by CAD therapy*
 3.0
 2.0-4.0
 [20]
ΔQALY Net QALY gained varies Equations 1c,2c [20]

*Over a 10-year follow-up period.

#Assumed to be myocardial infarction (or cerebral, for invasive angiography).

Angiography refers to invasive coronary angiography. Details of the parameters are given in the text.

CAD: coronary artery disease; CMR: cardiovascular magnetic resonance; N/A: not applicable; QALY: quality-adjusted life-year; SPECT: single-photon emission computed tomography.