Table 1. Characteristics of sham-operated and 4/6-nephrectomized (4/6NX) rats at sacrifice.
| Sham-operated | 4/6NX | ||||
| Placebo (n = 4) | Placebo (n = 4) | Losartan (n = 4) | Moxonidine (n = 4) | p (K-W) | |
| Body weight (g) | 494±45 | 495±13 | 438±41 | 446±21 | NS |
| Kidney/body weight (mg/g) | 6.0±0.1 | 6.4±0.5 | 5.8±0.3 | 5.8±0.3 | NS |
| Blood pressure (mm Hg) | 128±9 | 149±14 | 131±5 | 129±2 | NS |
| ClCreatinine (ml/min/1g kidney) | 0.86±0.13 | 0.68±0.03 | 0.86±0.09 | 0.74±0.09 | NS |
| Proteinuria (mg/µmol crea) | 175±30 | 603±205+ | 174±14* | 307±54 | 0.024 |
| Serum AGE/Albumin (AU/g) | 4.4±0.3 | 6.3±0.7+ | 6.1±0.1 | 5.1±0.1* | 0.048 |
| Serum AOPPs/Albumin (µmol/g) | 4.5±0.5 | 5.8±1.3 | 2.4±0.7* | 5.5±0.2 | 0.039 |
Cl: clearance; AGE: advanced glycation end products-associated fluorescence of plasma; AU: arbitrary units; AOPPs: plasma advanced oxidation protein products; K-W: Kruskal-Wallis test;
+: p<0.05 vs. SHAM-PLAC;
*
: p<0.05 vs. 4/6NX-PLAC (Exact 2-sided Man-Whitney U-test with Bonferonni correction).