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. 2013 Jun 20;9(6):e1003544. doi: 10.1371/journal.pgen.1003544

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© 2013 Xie et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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M-mode traces reveal the positions of the Drosophila heart wall edges (Y direction) over time (X direction). M-modes from hearts expressing wild type CryAB exhibit fairly regular contraction and relaxation cycles. However, movement traces of cardiac tubes expressing mutant CryAB^R120G reveal hearts with dilated dimensions, a lower extent of shortening and arrhythmic beating patterns relative to controls. M-modes from hearts expressing mutant CryAB^R120G and Zw (G6PD) RNAi suggest that knockdown of G6PD increases heart rate, promotes rhythmic beating patterns and rescues the cardiac tube dimensions of the mutant hearts.