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. 2013 Jun 20;9(6):e1003454. doi: 10.1371/journal.ppat.1003454

Figure 5. IL-10 production by T cells is required for Brucella abortus persistence and for control of pathology in vivo.

Figure 5

(A, B) B. abortus 2308 CFU counts in spleen (A) and liver (B) from littermate control (grey bars) compared with IL10flox/CD4Cre mice (white bars) at 3, 9, 21 and 42 d.p.i. (C) Measurement of mouse weight over time in grams of littermate control mice (grey dots) compared with IL10flox/CD4Cre mice (white dots). (D) ELISA essay for IL-6 and TNF-α production in serum from littermate control mice (grey bars) compared with IL10flox/CD4Cre mice (white bars) at 3, 9, 21 and 42 d.p.i. (E) qRT-PCR analysis of pro-inflammatory cytokines genes (Ifnγ, Il6 and Tnfα) in spleen from littermate control mice (grey bars) compared with IL10flox/CD4Cre mice (white bars) at 3, 9, 21 and 42 d.p.i. n = 5. Values represent mean ± SEM. (*) represents P<0.05 using unpaired t-test statistical analysis.