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. Author manuscript; available in PMC: 2014 Jun 17.
Published in final edited form as: Ann Neurol. 2013 Jun 17;73(6):741–750. doi: 10.1002/ana.23873

FIGURE 5.

FIGURE 5

NTG-evoked delayed sensitization of meningeal nociceptors sensitization involves pERK. Changes in threshold (A) and suprathreshold (B) responses of meningeal nociceptors to mechanical stimulation of the dura 180 and 360 min following infusion with NTG alone (7 Aδ, 9 C), NTG infusion followed by local MEK inhibition using U0126 (6 A-δ, 6 C) or PD98059 (3 A-δ, 5 C) or local treatment with U0126 (4 A-δ 5C) or PD98059 (4 A-δ 5C) alone. (*p < 0.05, Mann Whitney test NTG alone vs NTG+MEK inhibitors).