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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Apr 6;1830(9):4314–4320. doi: 10.1016/j.bbagen.2013.03.033

Figure 3. Fn influences cell behavior in response to control and tumor ECMs.

Figure 3

Addition of the control peptide Del29 during preparation of tumor ECMs does not alter Fn incorporation, whereas addition of the Fn polymerization inhibitor pUR4 markedly decreased Fn incorporation. Scale bar = 20 μm (A). Accordingly, tumor matrices prepared in the presence of pUR4 increased cell adhesion as determined by counting of trypsinized cells (B) and diminished VEGF secretion as analyzed via ELISA followed by normalization to cell number (C) to levels comparable to control matrices. * indicates p < 0.05.