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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Apr 6;1830(9):4314–4320. doi: 10.1016/j.bbagen.2013.03.033

Figure 5. Conducting polymer films to define the effect of Fn conformation on adhesion and VEGF secretion.

Figure 5

Oxidized (+1V) or reduced (−1V) PEDOT:PSS surfaces were coated with media containing either fibronectin (Fn) only, or 10% serum (containing Fn), to establish compact and partially unfolded conformations of adsorbed Fn, respectively. The number of 3T3-L1 cells per well adhered to unfolded Fn was decreased relative to compact Fn (A), while an opposite effect was detected for VEGF secretion (B) for both Fn and serum-coated devices. These differences were determined by image analysis of DAPI-stained fixed devices and VEGF ELISA followed by normalization to cell number. * indicates p < 0.05.