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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2013 Mar 14;25(3):357–364. doi: 10.1016/j.ceb.2013.02.015

Figure 2. DNA and chromatin features in breakage susceptibility.

Figure 2

DNA sequence features (green), histone modifications (yellow), and chromatin structure (red) may facilitate breakage susceptibility and represent an important upstream event in translocation formation. (right) The combined effect of sequence and chromatin features is evident in prostate cancer, where liganded androgen receptor (AR) recruits AID and TOP2B to translocation breakage sites.